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약학대학 - 약학대학

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  • 교수 약리학
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관심분야 

Pharmacogenomic study for personalized medicine
Drug metabolizing enzymes and transporters
Cardiovascular pharmacology and neuropharmacology

학력

  • (Ph.D.) Catholic University Medical College, Korea (1989)

약력/경력

  • 1999~ : Chairman, Dep. of Clinical Pharmacy, Graduate School of Professional Studies,Sungkyunkwan University
  • 1997~ : Associate and Full Professor, Sungkyunkwan University
  • 1988~2007 : Associate Professor, Catholic University Medical College

학술지 논문

  • (2024)  Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism.  ARCHIVES OF PHARMACAL RESEARCH.  47,  2
  • (2024)  PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes.  ARCHIVES OF PHARMACAL RESEARCH.  47,  1
  • (2023)  Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes.  ARCHIVES OF PHARMACAL RESEARCH.  46,  11-12
  • (2023)  Adinazolam, a Benzodiazepine-Type New Psychoactive Substance, Has Abuse Potential and Induces Withdrawal Symptoms in Rodents.  ACS CHEMICAL NEUROSCIENCE.  14,  18
  • (2023)  Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone.  ARCHIVES OF PHARMACAL RESEARCH.  46,  8
  • (2023)  Designer Drug, 25D-NBOMe, Has Reinforcing and Rewarding Effects through Change of a Dopaminergic Neurochemical System.  ACS CHEMICAL NEUROSCIENCE.  14,  15
  • (2023)  Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects.  ARCHIVES OF PHARMACAL RESEARCH.  46,  5
  • (2023)  Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects.  ARCHIVES OF PHARMACAL RESEARCH.  46,  2
  • (2022)  Physiologically based pharmacokinetic (PBPK) modeling of flurbiprofen in different CYP2C9 genotypes.  ARCHIVES OF PHARMACAL RESEARCH.  45,  8
  • (2022)  Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes.  ARCHIVES OF PHARMACAL RESEARCH.  45,  6
  • (2022)  Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism.  ARCHIVES OF PHARMACAL RESEARCH.  45,  5
  • (2022)  Effects of CYP2C9*3 and *13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects.  ARCHIVES OF PHARMACAL RESEARCH.  45,  2
  • (2021)  Physiologically based pharmacokinetic (PBPK) modeling of meloxicam in different CYP2C9 genotypes.  ARCHIVES OF PHARMACAL RESEARCH.  44,  12
  • (2021)  Physiologically based pharmacokinetic modeling of candesartan related to CYP2C9 genetic polymorphism in adult and pediatric patients.  ARCHIVES OF PHARMACAL RESEARCH.  44,  12
  • (2021)  Physiologically based pharmacokinetic (PBPK) modelling of tamsulosin to related CYP2D6*10 allele.  ARCHIVES OF PHARMACAL RESEARCH.  44,  11
  • (2021)  Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism.  ARCHIVES OF PHARMACAL RESEARCH.  44,  7
  • (2020)  Effects of paroxetine on the pharmacokinetics of atomoxetine and its metabolites in different CYP2D6 genotypes.  ARCHIVES OF PHARMACAL RESEARCH.  43,  12
  • (2020)  ABCB1 c.2677G>T/c.3435C>T diplotype increases the early-phase oral absorption of losartan.  ARCHIVES OF PHARMACAL RESEARCH.  43,  11
  • (2020)  Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide.  ARCHIVES OF PHARMACAL RESEARCH.  43,  11
  • (2020)  Flavonoids as therapeutic candidates for emotional disorders such as anxiety and depression.  ARCHIVES OF PHARMACAL RESEARCH.  43,  11

단행본

  • (2018)  약물학.  범문에듀케이션.  주저자
  • (2016)  약국실무.  신일상사.  공동
  • (2016)  약물학 정리와 시험.  신일북스.  공동
  • (2015)  약물작용 기본이론.  군자촐판.  주저자
  • (2015)  약물.  범문에듀케이.  주저자
  • (2014)  약물치료학요약집.  신일북.  공동
  • (2014)  약국실무요점.  신일북스.  공동
  • (2014)  기초약무실습.  신일북.  공동
  • (2014)  약물치료학.  신일북.  공동
  • (2013)  약물작용 기초이론.  군자출판사.  주저자
  • (2013)  임상약리와 약물치료.  신일북스.  주저자
  • (2012)  기초약무실습.  신일북스.  공동
  • (2012)  약리학 정리와 시험.  신일북스.  공동
  • (2012)  약물학.  신일북스.  공동
  • (2012)  약학입문.  신일북스.  주저자
  • (2011)  약물상호작용.  신일상사.  주저자
  • (2009)  약물치료학.  신일상사.  주저자
  • (2009)  약물학.  신일북스.  주저자
  • (2008)  하버드 핵심약리학.  이퍼블릭.  공동
  • (2007)  약제별복약지도.  약사공론.  공동

특허/프로그램

  • CYP2C9유전자의 유전형을 이용한 멜록시캄의 약물반응 예측방법.  10-2012-0097359.  20141106.  대한민국
  • CYP2C9유전자의 유전형을 이용한 자피루카스트의 약물반응 예측방법.  10-2012-0097360.  20140709.  대한민국
  • 베르베린을 유효성분으로 함유하는 모르핀류 중독, 또는 진통 내성 형성 예방, 억제용 약재.  200380102287.9.  20100505.  중국
  • 베르베린을 유효성분으로 함유하는 모르핀류 중독, 또는 진통 내성 형성 예방, 억제용 약재.  2005-501862.  20100430.  일본
  • 약물의존종독을 예방 및 치료하기 위한 바닐로이드 수용체 길항제.  00000000.  20070912.  대한민국
  • Pharmacological composition containing berberine as effective ingredient for preventing and treating addiction or tolerance to morphine.  US 7,250,422 B2.  20070731.  미국
  • Apicidin-derovatives, their synthetic methods, and antitumor compositions containing the same.  US6831061 B2.  20041214.  미국
  • 애피시딘 유도체, 이의 합성방법 및 이를 포함하는 항암제조성물.  0456047.  20041028.  대한민국

학술회의논문

  • (2021)  Development of physiologically based pharmacokinetic (PBPK) model for meloxicam related to CYP2C9 genetic polymorphism.  2021 대한약학회 추계학술대회.  대한민국
  • (2021)  Physiologically based pharmacokinetic (PBPK) modeling and simulation for risperidone and its active metabolite related to CYP2D6 genetic polymorphism.  2021 대한약학회 추계학술대회.  대한민국
  • (2021)  Physiologically based pharmacokinetic (PBPK) modeling of gliclazide in different CYP2C9 and CYP2C19 genotypes.  2021 대한약학회 추계학술대회.  대한민국
  • (2021)  Physiologically based pharmacokinetic (PBPK) modeling of tamsulosin related to CYP2D6*10 allele.  2021 대한약학회 추계학술대회.  대한민국
  • (2021)  Physiologically based pharmacokinetic modeling of omeprazole, proton pump inhibitor, considering CYP2C19 genetic polymorphism in humans.  2021 대한약학회 추계학술대회.  대한민국
  • (2021)  Simulation of candesartan physiologically based pharmacokinetic model according to CYP2C9 genetic polymorphism.  대한약학회 추계학술대회.  대한민국
  • (2020)  CORRELATION PREDICTION BETWEEN PROPRANOLOL PHARMACOKINETICS AND CYP2D6 GENETIC POLYMORPHISM USING PBPK MODEL.  대한약리학회 추계학술대회.  대한민국
  • (2020)  DEVELOPMENT OF VORICONAZOLE PBPK MODEL BASED ON CYP2C19 GENETIC POLYMORPHISM USING IN VITRO METABOLISM.  대한약리학회 추계학술대회.  대한민국
  • (2020)  Effect of CYP2D6 genetic polymorphism on metoclopramide in adults and children: using physiologically based pharmacokinetic modeling.  대한약리학회 추계학술대회.  대한민국
  • (2020)  PBPK MODELING OF THE EFFECT OF CYP2D6 ENZYME GENETIC POLYMORPHISM ON THE PHARMACOKINETICS OF OPIOID DRUG.  대한약리학회 추계학술대회.  대한민국
  • (2020)  PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING: EFFECT OF CYP2C9 GENETIC POLYMORPHISM ON CANDESARTAN IN PEDIATRIC.  대한약리학회 추계학술대회.  대한민국
  • (2020)  PREDICTION OF CYP2C9 GENETIC POLYMORPHISM OF FLURBIPROFEN USING PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING.  대한약리학회 추계학술대회.  대한민국
  • (2020)  SIMULATION OF RISPERIDONE AND ITS METABOLITE, PALIPERIDONE PARMACOKINETIC MODEL ACCORDING TO CYP2D6 GENOTYPES.  대한약리학회 추계학술대회.  대한민국
  • (2020)  THE PHARMACOKINETICS PREDICTION OF TAMSULOSIN ASSOCIATED WITH CYP2D6 GENETIC FACTOR USING PBPK MODEL.  대한약리학회 추계학술대회.  대한민국
  • (2020)  Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation of Lornoxicam to Develop Personalized Drug Optimization regarding to CYP2C9 Genetic Polymorphism.  Experimental Biology 2020.  미국
  • (2020)  Physiologically Based Pharmacokinetic Modeling of Propranolol in Relation to CYP2D6 Genotypes.  Experimental Biology 2020.  미국
  • (2020)  Prediction of Flurbiprofen Pharmacokinetics by CYP2C9 Genotypes in Populations Utilizing a Physiological Based Pharmacokinetic Modeling.  Experimental Biology 2020.  미국
  • (2019)  AG-OX, a potent inhibitor of interactions between S100A9 and RAGE/TLR4, selectively inhibits S100A9-positive triple-negative breast cancer.  ASCEPT_PAGANZ 2019 Joint Scientific Meeting.  뉴질랜드
  • (2019)  Estimating concentration of venlafaxine and its metabolite in case of enzyme polymorphism and renal impairment.  ASCEPT_PAGANZ 2019 Joint Scientific Meeting.  뉴질랜드
  • (2019)  Prediction of flurbiprofen pharmacokinetics from using in vitro metabolism data in relation to CYP2C9 genetic polymorphism..  ASCEPT_PAGANZ 2019 Joint Scientific Meeting.  뉴질랜드